Principal Scientist Quantitative Systems Pharmacology
Company: Sanofi
Location: Cambridge
Posted on: March 13, 2026
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Job Description:
Job title : Principal Scientist Quantitative Systems Location:
Cambridge, MA About the Job We are an innovative global healthcare
company with one purpose: to chase the miracles of science to
improve peoples lives. Were also a company where you can flourish
and grow your career, with countless opportunities to explore, make
connections with people, and stretch the limits of what you thought
was possible. Are you ready to shape the future of medicine? The
race is on to speed up drug discovery and development to find
answers for patients and their families. Your skills could be
critical in helping teams accelerate progress. Join our
Quantitative Systems Pharmacology (QSP) group as a Principal
Scientist and you'll support our R&D portfolio with mechanistic
disease modeling. Join the engine of Sanofis mission where deep
immunoscience meets bold, AI-powered research. In R&D, youll
drive breakthroughs that could turn the impossible into possible
for millions. About Sanofi: Were an R&D-driven, AI-powered
biopharma company committed to improving peoples lives and
delivering compelling growth. Our deep understanding of the immune
system and innovative pipeline enables us to invent medicines and
vaccines that treat and protect millions of people around the
world. Together, we chase the miracles of science to improve
peoples lives. Main Responsibilities: Function as part of a team to
develop and apply multiscale computational models of complex
diseases based on detailed biological mechanistic knowledge to
support model-informed drug discovery & development. Survey
literature to gain understanding of critical physiological
processes to be represented, and identify suitable mechanistic
elements, data, parameters and assumptions to be included. Identify
and analyze suitable internal preclinical and clinical data to
inform modeling activities. Analyze simulation results and identify
appropriate strategies to resolve issues pertaining to model
performance and accuracy. Maintain extensive documentation of model
development process, and data analysis. Maintain quantitative
systems pharmacology expertise through comprehensive education
Communicate modeling predictions to key stakeholders. About You
Basic Qualifications: PhD in systems pharmacology/biology,
computational biology, biomedical engineering, or a related field
with a strong record of productivity demonstrated through
publications and scientific presentations with at least 2 years of
Postdoctoral experience in disease modeling/QSP Masters degree with
4 years of relevant industry experience Proficiency in mathematical
modeling using differential equations. Extensive experience in
computational tools such as MATLAB, Julia and R (MATLAB preferred).
Desirable Qualifications: Experience in drug discovery/development
a plus, especially in bioinformatics or pharmacometrics. Knowledge
of Immunology Soft Skills: Excellent oral and written communication
skills. Ability to quickly learn pathophysiology in indications of
interest, and treatment approaches in immunology. Highly motivated,
detail-oriented, and independent researcher. Able to thrive in a
collaborative, multi-disciplinary team environment. Strong
commitment to on-the-job-training. Why Choose Us Bring the miracles
of science to life alongside a supportive, future-focused team.
Discover endless opportunities to grow your talent and drive your
career, whether its through a promotion or lateral move, at home or
internationally. Enjoy a thoughtful, well-crafted rewards package
that recognizes your contribution and amplifies your impact. Take
good care of yourself and your family, with a wide range of health
and wellbeing benefits including high-quality healthcare,
prevention and wellness programs and at least 14 weeks
gender-neutral parental leave. Be part of a pioneering biopharma
company that engages patients early in drug development and uses
their insights to design studies that reflect real-world needs.
Help improve the lives of millions of people globally by making
drug development quicker and more effective. Work at the forefront
of drug discovery, harnessing cutting-edge AI, data, and digital
platforms to push the boundaries of science. Sanofi Inc. and its
U.S. affiliates are Equal Opportunity and Affirmative Action
employers committed to a culturally diverse workforce. All
qualified applicants will receive consideration for employment
without regard to race; color; creed; religion; national origin;
age; ancestry; nationality; marital, domestic partnership or civil
union status; sex, gender, gender identity or expression;
affectional or sexual orientation; disability; veteran or military
status or liability for military status; domestic violence victim
status; atypical cellular or blood trait; genetic information
(including the refusal to submit to genetic testing) or any other
characteristic protected by law. All compensation will be
determined commensurate with demonstrated experience. Employees may
be eligible to participate in Company employee benefit programs,
and additional benefits information can be found here.
Keywords: Sanofi, Methuen , Principal Scientist Quantitative Systems Pharmacology, Science, Research & Development , Cambridge, Massachusetts
