Head of Chemistry

Company: Mariana Oncology
Location: Watertown
Posted on: February 20, 2026

Job Description:

Job Description Job Description Salary: Reporting: Head of Mariana Research Description: We are seeking an experienced Head of Chemistry to join and lead Marianas Chemistry organization, advancing personalized medicine and radiopharmaceuticals. Illustrative Breadth of Responsibilities: Lead, mentor, and develop a growing team of chemistry professionals, fostering a collaborative and innovative environment. Set the strategic direction for the chemistry function, ensuring alignment with the companys overall scientific and business objectives. Drive the design, synthesis, and optimization of novel radiopharmaceutical drug candidates, ensuring they meet preclinical requirements for potency, selectivity, and ADME properties. Provide scientific and strategic guidance to cross-functional teams (including biology, radiopharmacology, preclinical development, imaging, and clinical development) to advance projects through discovery and development. Evaluate assay and instrument performance, ability to troubleshoot issues. Collaborate with internal and external partners to integrate cutting-edge technologies and methodologies (e.g., structure-based design, computational chemistry, medicinal chemistry) to accelerate drug discovery. Stay ahead of emerging trends and innovations in medicinal chemistry and oncology to ensure the company remains at the forefront of the field. Lead the timely delivery of key milestones in the drug discovery process, from hit identification through lead optimization; support preclinical development, translational, and clinical activities. Promote professional development opportunities for team members through mentorship, training, and career advancement. Effectively manage the teams workload and distribution to ensure proper load management and optimize each programs chance for success based on each individuals strengths. Oversee effective CRO management for external vendors to optimize value, efficiency, and speed. Partner with senior leadership to shape the company's R&D pipeline and identify new opportunities to address critical oncology challenges. Requirements/Skills: Ph.D. in Chemistry (Medicinal Chemistry, Organic Chemistry, or related field) with a strong record of achievement in oncology drug discovery. 12 years of experience in the pharmaceutical or biotechnology industry, with at least 5 years in a leadership role. Proven track record of success in leading chemistry teams and advancing oncology drug candidates to development candidates and beyond. Strong leadership and management skills, with a demonstrated ability to inspire and guide cross-functional teams. In-depth knowledge of medicinal chemistry principles, drug design strategies, and preclinical drug development. Expertise in synthetic organic chemistry, structure-based drug design, and/or computational chemistry is highly desirable. Experience in peptides is highly preferred. Experience in targeted radiopharmaceuticals is preferred but not required. Demonstrated track record of success in oncology is required. Strong problem-solving, analytical, and decision-making skills. Excellent communication and presentation skills, with the ability to articulate complex scientific concepts to both technical and non-technical stakeholders. Strategic thinker with the ability to manage multiple priorities in a fast-paced, dynamic environment. Mariana Oncologys Principles Building a Legacy Execution Excellence Courage of our Convictions Mariana Oncology Compensation Summary: The salary for this position is expected to range between $189,420.00 and $351,000.00 per year. Your compensation will also include a performance-based cash incentive. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and will be reviewed periodically upon joining Mariana Oncology. Mariana may change the published salary range based on company and market factors. US-based eligible employees will receive a comprehensive benefits package that includes a strong health insurance package, life insurance, disability benefits, a 401(k) with company contribution and match, tuition reimbursement, and a variety of other benefits. In addition, employees are eligible for a generous flexible time off program.

Keywords: Mariana Oncology, Methuen , Head of Chemistry, Science, Research & Development , Watertown, Massachusetts