Manager, Supply Chain Planning

Company: Dyne Therapeutics
Location: Waltham
Posted on: March 2, 2026

Job Description:

Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/ , and follow us on X , LinkedIn and Facebook . Role Summary: The Manager, Supply Chain Planning is responsible for end-to-end inventory and production planning across Dyne’s external supply network. This includes long-range planning (LRP), ensuring uninterrupted clinical supply, and supporting commercial launch readiness through scenario-based planning and risk assessments. This tactical role is critical in executing current planning activities and shaping future supply chain capabilities. The Manager collaborates cross-functionally with internal stakeholders (e.g. the wider CMC team, Regulatory, Quality, Clinical Operations, and Commercial teams) as well as external partners and service providers. This is a full-time position based in Waltham, MA Primary Responsibilities Include: Production Planning Collaborate with cross-functional partners in Technical Operations, Logistics, Quality, Clinical Operations, and Commercial to develop and maintain a reliable demand and supply plan, ensure supply continuity, uninterrupted clinical supply for patients, support commercial readiness, and align with the company’s business objectives. Maintain an understanding of external manufacturing site capacities, capabilities, and supply risks. Perform scenario planning to evaluate alternative demand and supply assumptions and inform risk mitigation strategies. Maintain vendor forecasts in alignment with clinical and commercial demand forecasts as well as contracted minimum production requirements. Balance production across supply network to maintain set inventory targets Manage master data, demand forecasts, and accurate stock levels in SCmple Supply Chain Planning tool. Manage purchase orders and invoice reconciliation from external vendor network. Support the Implementation of an Enterprise Resource Planning (ERP) system. Logistics Operations Support Coordinate and oversee shipments of materials between CMOs, warehouses, 3PLs, Test Labs and other supply chain nodes. Support network re-supply, working closely with internal stakeholders (Quality, Manufacturing) and external partners (couriers, CMOs, customs brokers, and warehouse providers). Ensure timely and compliant shipments, including documentation preparation, booking, tracking, and post-shipment follow-up, closure and archiving. Troubleshoot logistics issues and implement corrective actions as needed. Compliance & Documentation Ensure all planning and logistics activities are conducted in compliance with GMP, GDP, and other applicable regulations. Author, implement and maintain the necessary Supply Chain-related standard operating procedures (SOPs) and work instructions. Collaborate with Quality and Regulatory teams to ensure proper handling of clinical and commercial materials. Collaborate with cross-functional teams to establish processes and capabilities to support ongoing clinical operations and future commercial operations. Education, Experience, and Skills Requirements: Bachelor’s degree in Life Sciences, or related field; Advanced degree or certification is a plus 5 years total experience, 3 years in supply chain planning, preferably within the pharmaceutical or biotech industry Ability to effectively plan, prioritize, execute, follow up and anticipate challenges Experience managing complex schedules and priorities in dynamic pharmaceutical, biotech or related environments Ability to work, influence, and gain agreement across multiple functions Strong analytical, problem solving, and critical thinking skills Experience with ERP system implementation Proficiency in Excel and familiarity with planning and analytics tools such as Smartsheet, Visio, ERP systems (e.g., SAP, Oracle), and Power BI Collaborative work style to be part of a team to identify process gaps and develop solutions Excellent interpersonal, verbal, and written communication skills Experience supporting clinical and/or commercial supply chains Operational experience managing material movements across global CMOs, 3PLs, warehouses, and Test Labs Working knowledge of GMP/GDP standards Proactive problem solver with the ability to operate independently in a fast-paced environment High attention to detail and organizational skills Ability to manage multiple priorities and stakeholders simultaneously LI-Onsite MA Pay Range $122,000 - $150,000 USD The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills. The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload. Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

Keywords: Dyne Therapeutics, Methuen , Manager, Supply Chain Planning, Logistics, Transportation & Drivers , Waltham, Massachusetts